Recent publications

Semmaphorin 3 A causes immune suppression by inducing cytoskeletal paralysis in tumour-specific CD8⁺ T cells.

Barnkob MB, Michaels YS, André V, Macklin PS, Gileadi U, Valvo S, Rei M, Kulicke C, Chen JL, Jain V, Woodcock VK, Colin-York H, Hadjinicolaou AV, Kong Y, Mayya V, Mazet JM, Mead GJ, Bull JA, Rijal P, Pugh CW, Townsend AR, Gérard A, Olsen LR, Fritzsche M, Fulga TA, Dustin ML, Jones EY, Cerundolo V.Nat Commun. 2024 Apr 12;15(1):3173. doi: 10.1038/s41467-024-47424-z.PMID: 38609390

Engineering T Cell Development for the Next Generation of Stem Cell-Derived Immunotherapies.

Michaels YS, Durland LJ, Zandstra PW.GEN Biotechnol. 2023 Apr 1;2(2):106-119. doi: 10.1089/genbio.2023.0008. Epub 2023 Apr 18.PMID: 37928777

Interrogation of Functional miRNA-Target Interactions by CRISPR/Cas9 Genome Engineering. 2nd edition

Wu Q, Michaels YS, Fulga TA.Methods Mol Biol. 2023;2630:243-264. doi: 10.1007/978-1-0716-2982-6_16.PMID: 36689187

Synthetic gene circuits for cell state detection and protein tuning in human pluripotent stem cells.

Prochazka L, Michaels YS, Lau C, Jones RD, Siu M, Yin T, Wu D, Jang E, Vázquez-Cantú M, Gilbert PM, Kaul H, Benenson Y, Zandstra PW.Mol Syst Biol. 2022 Nov;18(11):e10886. doi: 10.15252/msb.202110886.PMID: 36366891 Free PMC article.

DLL4 and VCAM1 enhance the emergence of T cell-competent hematopoietic progenitors from human pluripotent stem cells.

Michaels YS, Edgar JM, Major MC, Castle EL, Zimmerman C, Yin T, Hagner A, Lau C, Hsu HH, Ibañez-Rios MI, Durland LJ, Knapp DJHF, Zandstra PW.Sci Adv. 2022 Aug 26;8(34):eabn5522. doi: 10.1126/sciadv.abn5522. Epub 2022 Aug 24.PMID: 36001668 Free PMC article.

Multi-objective optimization reveals time- and dose-dependent inflammatory cytokine-mediated regulation of human stem cell derived T-cell development.

Edgar JM, Michaels YS, Zandstra PW.NPJ Regen Med. 2022 Jan 27;7(1):11. doi: 10.1038/s41536-022-00210-1.PMID: 35087040 Free PMC article.

FOXN1 forms higher-order nuclear condensates displaced by mutations causing immunodeficiency.

Rota IA, Handel AE, Maio S, Klein F, Dhalla F, Deadman ME, Cheuk S, Newman JA, Michaels YS, Zuklys S, Prevot N, Hublitz P, Charles PD, Gkazi AS, Adamopoulou E, Qasim W, Davies EG, Hanson I, Pagnamenta AT, Camps C, Dreau HM, White A, James K, Fischer R, Gileadi O, Taylor JC, Fulga T, Lagerholm BC, Anderson G, Sezgin E, Holländer GA.Sci Adv. 2021 Dec 3;7(49):eabj9247. doi: 10.1126/sciadv.abj9247. Epub 2021 Dec 3.PMID: 34860543 Free PMC article.

Emerging Approaches for Regulation and Control of CAR T Cells: A Mini Review.

Brandt LJB, Barnkob MB, Michaels YS, Heiselberg J, Barington T.Front Immunol. 2020 Feb 26;11:326. doi: 10.3389/fimmu.2020.00326. eCollection 2020.PMID: 32194561 Free PMC article. Review.

Decoupling tRNA promoter and processing activities enables specific Pol-II Cas9 guide RNA expression.

Knapp DJHF, Michaels YS, Jamilly M, Ferry QRV, Barbosa H, Milne TA, Fulga TA.Nat Commun. 2019 Apr 2;10(1):1490. doi: 10.1038/s41467-019-09148-3.PMID: 30940799 Free PMC article.

Precise tuning of gene expression levels in mammalian cells.

Michaels YS, Barnkob MB, Barbosa H, Baeumler TA, Thompson MK, Andre V, Colin-York H, Fritzsche M, Gileadi U, Sheppard HM, Knapp DJHF, Milne TA, Cerundolo V, Fulga TA.Nat Commun. 2019 Feb 18;10(1):818. doi: 10.1038/s41467-019-08777-y.PMID: 30778069 Free PMC article.

In situ functional dissection of RNA cis-regulatory elements by multiplex CRISPR-Cas9 genome engineering.

Wu Q, Ferry QRV, Baeumler TA, Michaels YS, Vitsios DM, Habib O, Arnold R, Jiang X, Maio S, Steinkraus BR, Tapia M, Piazza P, Xu N, Holländer GA, Milne TA, Kim JS, Enright AJ, Bassett AR, Fulga TA.Nat Commun. 2017 Dec 13;8(1):2109. doi: 10.1038/s41467-017-00686-2.PMID: 29235467 Free PMC article.

Interrogation of Functional miRNA-Target Interactions by CRISPR/Cas9 Genome Engineering.

Michaels YS, Wu Q, Fulga TA.Methods Mol Biol. 2017;1580:79-97. doi: 10.1007/978-1-4939-6866-4_7.PMID: 28439828

Thiolated uridine substrates and templates improve the rate and fidelity of ribozyme-catalyzed RNA copying.

Prywes N, Michaels YS, Pal A, Oh SS, Szostak JW.Chem Commun (Camb). 2016 May 5;52(39):6529-32. doi: 10.1039/c6cc02692c.PMID: 27109314

Recent publications

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